SOM content affects the yield and quality of flue-cured tobacco. SOM content could be influenced by the soil parent material. 42 surface soil samples and 165 soil profile samples were collected and analyzed from 7 main flue-cured tobacco planting counties in the central region of Guizhou Province. The results showed that SOM content ranged from 24.3g/kg to 31.6g/kg, with a mean of 27.7g/kg and variation coefficient of 9.48%, SOM content was within the 3rd grade in the fertility standard of the 2nd National Soil Survey, suitable for flue-cured tobacco planting. Correlative analysis showed that SOM content was extremely significantly positively correlated with the altitude. The SOM content of soil developed from gully debris was significantly higher than those developed from quaternary red clay and carbonate residual-slope wash. In profile vertical direction, SOM content showed strong surface-aggregation and decreased fast with soil depth. The SOM content of same horizon which formed from different parent material was in an order of gully debris > quaternary red clay > carbonate residue-slope wash.