The sensitivity of soil salinization can reflect the interference degree of the regional ecological environment. The dynamic monitoring of soil salinization sensitivity in 1989—2015 was analysed based on Landsat series remote sensing data by GIS and RS technology. The results indicated that:1) The high sensitivity was mainly distributed in the desert regions and the alluvial fan margin, while the extreme sensitivity was distributed around Manasi Lake and the irrigation area; 2) The areas of moderate sensitivity changed into height and into light sensitivities were 3 342.10 km² and 1 910.27 km², respectively, and the areas of high sensitivity into moderate and extreme sensitivities were 1 076.64 km² and 1 098.33 km² from 1989 to 2000 years, respectively. The area of moderate sensitivity into light sensitivity was 1 410.68 km², and the area of high sensitivity into moderate sensitivity was 2 713.74 km²; 3) Soil salinization sensitivity is higher in the alluvial fan margin and the reservoir surrounding of Manasi River Valley, thus the management of water resources and salinization should be strengthened;4) The changes of moderate sensitivity and high sensitivity into other grades were intense. Moderate sensitivity changed in a “V” pattern, and the decrease was greater than the increase; High sensitivity changed in an inverted “V” pattern, and the decrease was greater than the increase. The area of extreme sensitivity increased by 1.9%. In general, the management of soil salinization achieved certain effects, and the salinization in alluvial fan margin reduced obviously, this study is of significant in maintaining the regional safety and sustainability of soil resources.