Antibiotics are constantly used in human, plants and veterinary treatments. A huge percentage of these administered antibiotics, unchanged or transformed into their metabolites, are ultimately excreted into the soil via various ways, which leads to soil pollution and threatens to human health. Based on the researches in the recent years, this paper summarized the adsorption mechanism and influences of soil minerals, organic matter, solution and organisms to antibiotics and prospected the future research fields in order to provide theoretical references for the prevention and treatment of antibiotics pollution in the soil.