A pot experiment was conducted to study the effects of soil compaction on the growth of Sedum plumbizincicola and its uptake of cadmium (Cd) and zinc (Zn). Soils of different textures (clay, loamy clay and sandy loam) were treated respectively with no compaction, low-level compaction and high-level compaction. In comparison to no compaction, soil compaction resulted in significant decreases in shoot biomass of Sedum plumbizincicola by 66.8%-83.5%, 59. 9%-60.4% and 57.9%-71.4% in sandy loam, loamy clay and clay soils, respectively. However, the root activity was significantly improved by 142%-241% under high compaction treatment. In clay loam soil, high compaction resulted in significant decreases in Cd and Zn contents of shoot biomass. However, in sandy loam and clay soils, soil compaction had no significant effects on Cd and Zn contents of shoot biomass. In the respective sandy loam, loam clay and clay soils, soil compaction significant decreased Cd uptakes by 50.4%-73.8%, 61.4%-74.9% and 43.4%-63.3%, Zn uptakes by 48.7%-79.5%, 73.6%-79.0% and 46.1%-63.5%, respectively. Overall, soil compaction has the largest impacts on inhibiting the efficiencies of Cd and Zn uptakes by Sedum plumbizincicola in loam clay soil in the presenting study.