A field experiment was conducted to investigate the effects and differences of general commercial fertilizer and fermentation residues of CO₂ fertilization on the yield and quality of tomatoes. The results showed that the both fertilizers could enhance tomato yield, which increased by 24.02% and 28.59% than CK under general commercial fertilizer and fermentation residues of CO₂ fertilization treatments, respectively. And there was no significant difference between the two fertilizers. According to analyses on the indexes of the tomato quality, the fermentation residues of CO₂ fertilization significantly decreased the bad fruit rate and significantly promoted the concentrations of soluble sugar and vitamin C, for example, it deceased the bad fruit rate by 18.18% and 33.33% compared with general organic fertilizer and CK treatments, respectively. Therefore, the fermentation residues of CO₂ fertilization has the more advantages to enhance the tomato yield, decrease the bad fruit rates and promote the fruit quality.