Based on soil sampling data and remote sensing images in 1996, 2006 and 2016, the changes of soil salinity in Karamay agricultural development area with different reclamation years were analyzed by using statistic method and GIS and RS techniques. The results showed that: 1) In the past 20 years, soil salinization in the study area showed a general ecreasing trend, and the ‘severe-south and slight-north’ overall pattern of soil salinity did not change in the reclaimed land. 2) The study area was developed from north to south, and soil salt content decreased with the reclamation year, but salinity change in reclaimed area became more complicated since 2006. 3) In the study area, the reclamation conditions are better, soil salinization was lighter before reclamation, and reclamation reduced soil salinition which indicated an imporving effect of agricultural activities. Soil background conditions and the improving effect of agricultural activities became better with the increase of reclamation year. 4) Even after 10 years more of agricultural cultivation, some patchs with low NDVI in the south, soil salt contents were still high which hindered the crop growth.