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硒的生物学效应与环境相关性疾病的研究进展
熊咏民,杨晓莉,张丹丹,李 强,张 迪,李昭芳
西安交通大学医学部公共卫生学院地方病研究所,国家卫健委微量元素与地方病重点实验室
摘要:
微量元素硒是人体的必需微量元素,在人体内发挥着抗氧化、增强免疫力等重要功能。近年来越来越多的研究揭示硒还具有拮抗毒素、调节信号转导以及表观修饰等效应,这些新的研究进展为深入探索环境相关性疾病的病因、发病机制及防治提供了新的思路。本文就硒的生物学作用、表观修饰效应及其与环境相关性疾病的关系的研究进展进行综述,以期进一步深入探索微量元素硒的生物学潜能及健康效应,更好地造福于人类。
关键词:    表观修饰  健康效应  环境相关性疾病
DOI:10.13758/j.cnki.tr.2018.06.007
分类号:R12
基金项目:国家自然科学基金项目(81573104;81773372;81673117;81673115)资助。
Research Progress in Biological Function of Selenium and Environmentally Associated Diseases
XIONG Yongmin1,2, YANG Xiaoli1,2, ZHANG Dandan1,2, LI Qiang1,2, ZHANG Di1,2, LI Zhaofang1,2
1.Institute of Endemic Diseases, School of Public Health, Xi’an Jiaotong University Health Science Center;2.Key Laboratory of Trace Elements and Endemic Diseases, National Health Commission of the People’s Republic of China
Abstract:
Selenium is an essential trace element in human body and it exhibits critical functions of antioxidant and improvement immunity in human body. In recent years, more and more studies have revealed other effects of selenium such as antagonistic toxins, regulation of signal transduction and epigenetic modifications, and these novel researches provide new ideas for further exploration of the etiology, pathogenesis, and prevention and treatment of environmental-related diseases. In this paper, we reviewed the research progresses of selenium in biological effects, epigenetic modifications and its relationship with environmental associated diseases to further explore the biological potential and health effects of selenium for benefiting humankind better.
Key words:  Selenium  Epigenetic modifications  Health effects  Environmentally associated diseases

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