This paper analyzed pH and nutrients of 230 typical tobacco-growing soil samples from Shizhu County of Chongqing City in 2017 and compared the corresponding data of 2002 and 2017 in order to understand the condition and evolution of tobacco-growing soil fertility for the rational targeted fertilization strategies. The results showed that the average pH was 5.52 in 2017, soil samples with pH < 5.5 accounted for 49.1% of the total samples. The average SOM content was 30.67 g/kg in 2017, soil samples with SOM>20 g/kg accounted for 92.6% of the total samples. The average contents of soil alkali-hydrolyzed nitrogen, available phosphorus and available potassium were 156.35, 108.40 and 436.25 mg/kg respectively, with the proportions of soil samples at the high grades of 21.35%, 88.2% and 98.0% respectively. Compared with the data in 2002, 2012 and 2017, soil pH was decreased at first and then increased, SOM increased steadily, soil alkali-hydrolyzable nitrogen, available phosphorus and available potassium significantly increased. To sum up, soil acidification was serious and nutrients were exceedingly abundant. The integrated soil fertility was poor and declining. Hence, according to macro-strategy in huge restrict and small-adjustment in the field, through using fertilization zoning map and flue-cured tobacco formula fertilization card, specific fertilization program was put forward aiming at tobacco fields with different planting units to accomplish high-quality flue-cured tobacco production.