Soil bulk density is not only an important soil attribute that affects crop growth, but also an important goal of soil improvement. The understanding of the spatial distribution of soil bulk density and its influencing factors is helpful to the implementation of production management and soil improvement. In order to explore the spatial distribution of soil bulk density in Bijie of Guizhou Province, in total 653 topsoil samples (0-20 cm) were collected systematically from the typical tobacco-planting fields and soil bulk densities and mechanical compositions of the topsoil samples were determined. The spatial characteristics of soil bulk density were analyzed and the influencing factors were discussed. The results showed that the average bulk density in Bijie was 1.20 g/cm³ with a variation of 12.4%. In spatial, soil bulk density was higher in the west and lower in the middle. Soil parent material and type had significant impacts on soil bulk density. Soil derived from red weathering crust and sandy shale had the highest bulk density while coarse crystal had the smallest. Bulk density of the purple soil was the highest while the paddy soil was the smallest. Analysis showed that soil organic content was negatively related to soil bulk density. According to the plant growth and soil texture, soil bulk density should be improved in areas of Qixingguan and Weining for tobacco production.