In order to solve carbendazim and acetamiprid residues in vegetable soil, carbendazim degradation strain Rhodococcus qingshengii djl-6 and acetamiprid degradation strain Pigmentiphaga D-2 were used as materials to study the remediation effect and microecological effect of compound degradation bacteria on compound pesticide residue soil. The results show that:1) The optimum volume ratio of compound degradation strain djl-6:D-2 is 5:3, and the degradation rates of carbendazim and acetamiprid are 85.46% and 94.36% for 50 μg/ml respectively within 3 days. 2) When the initial inoculation amount is 7%, the degradation rates of 5 mg/kg carbendazim and acetamiprid in compound pesticide contaminated soil are 74.40% and 95.87% respectively within 6 days. When soil water content is 25%, the degradation rates of 5 mg/kg carbendazim and 5 mg/kg acetamiprid in soil contaminated by compound pesticides are 80.80% and 97.87%, respectively. 3) Soil contaminated by 10 mg/kg carbendazim and 10 mg/kg acetamiprid (compound pesticides) cause obvious drug damage to the growth of green vegetables. After growing for 24 days, the root length, stem and leaf length and fresh weight of green vegetables are only 66.56%, 58.35% and 45.13% of those of the blank control. Under the condition of 7% inoculation, the compound degradation bacteria can relieve the drug damage, and the growth index of green vegetables is consistent with that of the control. 4) Carbendazim and acetamiprid residues have significant inhibitory effects on Observed species index, Shannon index, Chao1 index and ACE index of soil bacterial community, which are positively correlated with the concentrations of carbendazim and acetamiprid. In conclusion, the compound degradation bacterial agent has a broad application prospect.