In order to investigate the effect of alpine wetland degradation on soil enzyme activities, this paper investigated the spatial and temporal characteristics of soil urease and protease activities in 0-10, 10-20 and 20-40 cm layers in Gahai wetlands on the eastern edge of the Qinghai-Tibetan Plateau with four different degraded gradients:not degraded, slightly degraded, moderately degraded and severely degraded. The results showed that soil water content decreased but temperature increased with the increase of the degradation. Soil urease activity decreased but protease activity increased gradually with the increase of degradation in the 0-40 cm layer; Except for severely degraded, the two enzyme activities decreased with the increase of soil depth. The activity was the highest in the 0-40 cm layer in July and August for urease and in June and July for protease, respectively; Soil urease activity was positively correlated with protease activity and temperature (P<0.01), while soil protease activity was positively correlated with microbial nitrogen (P<0.01), water content and temperature (P<0.05), and negatively correlated with nitrate nitrogen (P<0.05). The degradation of marshy meadows significantly increased urease activity but decreased protease activity in topsoil; temperature promoted soil urease and protease activities, and water content and microbial nitrogen promoted soil protease activity.