in situ chemical oxidation (ISCO) is the main technology for the remediation of refractory organic pollutants in soil groundwater, but there are some problems in its practical application, such as tailing rebound and after the application of oxidizer is stopped and pollution plume cannot be controlled. The slow-release technology can release oxidizer slowly in soil-groundwater polluted area, control oxidizer to stay in the effective concentration range for a long time, and solve the bottleneck problem of ISCO application in pollution remediation, which indicates that the slow-release technology has a very broad application prospect. Therefore, from the perspective of material preparation and application research, this review introduced the preparation methods of slow-release oxidants, remarked the release properties and primarily influencing factors of slow-release oxidants, and summarized the application performances of slow-release oxidants for degrading the organic pollutants in soil and groundwater. Finally, some suggestions were put forward for future application of the slow-release technology in ISCO according to the research status.