Inorder to explore the suitable integrated method of drip irrigation and top-dressing for tobacco, a field plot experiment was conducted, with the conventional dry fertilization as the control (CK), to study the effects of 2, 3, and 4 drip irrigation and top-dressing on the biomass of tobacco, soil mineral nitrogen contents, and the absorption and utilization of nitrogen, phosphorus, and potassium. Results showed that with the increase of drip fertigation times, the biomass of tobacco leaves and the whole plant at maturity stage, as well as the average content of soil mineral nitrogen during the vigorous growth stage and the whole growth stage, increased accordingly. Nitrogen and potassium contents in the leaves, as well as the accumulation and use efficiency of nitrogen, phosphorus, and potassium also increased. There was a significant correlation between nitrogen accumulation in the leaves and the whole plant at maturity stage and the average content of soil mineral nitrogen during the vigorous growth stage (r=0.526-0.816, P<0.01). Compared with CK, there was no significant difference in the utilization rates of nitrogen and potassium fertilizers under 2 and 3 times of drip fertigation. However, use efficiencies of nitrogen and potassium fertilizers were significantly improved by 57.7% and 58.5% (P<0.05) under 4 times of drip fertigation, while the use efficiency of phosphorus fertilizer significantly decreased by 35.7%-50.0% (P<0.05) under drip fertigation, with no significant difference among all fertigation treatments. Compared with 2 and 3 times of drip fertigation, 4 times of drip fertigation is more beneficial for maintaining and stabilizing soil mineral nitrogen content during the vigorous growth stage, promoting the growth, development, and nutrient absorption and utilization of tobacco plant, thus is most suitable for tobacco top-dressing in the experimental area.