In the moderate and light cadmium (Cd) polluted acidic paddy soils in the suburbs of Nanjing, two field experiments were conducted to study the reduction effects of soil conditioner ISS on rice Cd accumulation and the rice-Sedum plumbizincicola rotation on soil Cd, respectively. Compared with the control treatment, 1.5-4.5 t/hm² of ISS applications had no significant effect on rice yield, but significantly reduced Cd concentration in brown rice by 35.4%-54.3%, and the reduction of Cd concentration in brown rice increased with the increase of ISS application rate. One year after the application of ISS was stopped, Cd concentration in brown rice was still significantly reduced by 32.2%-44.2%, and Cd concentration in brown rice was insignificantly different from that of the previous year. There was also insignificant difference in Cd concentrations in brown rice between ISS and quicklime treatments under the same application rate, which further demonstrated the long-term effect and stability of ISS conditioner on the reduction of rice Cd accumulation. In the rotation system of rice and hyperaccumulator Sedum plumbizincicola, Cd concentration in brown rice was 0.19 mg/kg which was lower than the limit standard of 0.2 mg/kg (GB 2762—2022). The total uptakes of Cd in the shoots of rice and Sedum plumbizincicola were 11.1 g/hm² and 99.5 g/hm², which accounted for 1.00% and 8.96% of the total Cd of soil, respectively. Thus, the rotation of rice-Sedum plumbizincicola is a “phytoremediation coupled with agro-production” technology with great potential for the reduction remediation of Cd polluted soil.