This paper studied land use dynamic change and its spatial agglomeration in Ganzhou District from the perspective of land use change flow in order to provide instruction for land use spatial distribution of Ganzhou District, wetland protection and construction. The results showed that the proportion of natural reserved land was predominant in Ganzhou District, however, those of cultivated land, forestry land and grassland were very low, showed a large potential in reserved land resources for development available. The land use change of cultivated land, construction land and grassland played the important roles in land use change of Ganzhou District; the main land use change flows were cultivated land, grassland and natural reserved land. The activity of construction land increased constantly to 3.16% at the end of 2011, which was attributed to urban land expansion. The volatility of land use change happened mainly in the conversion between waters and forestry land, which reached 2.0000. The spatial distribution of land use change types composed a ring structure in the study area, which consisted of built-up region as the center, continued growing construction land as the inner ring, and converted grassland into cultivated land as the outer class. The spatial agglomeration of Ganzhou District revealed that the regions with a high land change rates were growing in number, expanded to south and overspread along the town and the river. The above results show that land use dynamic change and its spstial agglomeration are supplementary information in land use aspects of Ganzhou District, can be used to develop sustainably better.